I wanted to tell you guys about it because I feel smarter, healthier, and happier. I think nootropics can make the world a better place! People can be happy and healthy and get the benefits of "drugs" without the damage!
Ok I got into Nootropics, starting with dmae, then piracetam aniracetam and alphaGPC choline, I could see subtle improvement but I wanted to figure out how I could get even more cognitive benefits which led me to try a few other things.
A correct omega-3 ratio does wonders for your mood, I've heard that a good ratio is 1:1 with omega-6, however most people on a typical american diet can be off by as much as 1:50!
So, getting this in order greatly helps your overall sense of wellbeing.
First thing if you are starting on a nootropic regemin is diet and excersize, a proper diet with good nutrition is essential to a properly functioning mind, next thing I'm going to recommend to you is a good multi-vitamin such as Ortho-core, LEF Essential Mix, NOW Foods ADAM) and an Omega3 supplement (like Nutrasea)
Maximizing anti-oxidants helps you feel better overall, and vitamin C breaks down the stress hormone cortisol as well as helps in the building of neurotransmitters such as serotonin and dopamine.
I have read that in certain raw food diets they commonly intook up to 16 grams of vitamin C daily! The united states RDA is something like 60mg a day which is just barely enough to stop you from getting scurvy! A main reason not to take too much C is that it can cause a stomach ache or diarrhea, so I'd recommend a "buffered" C to help counteract that acidity.
I would recommend that you check out Aniracetam Piracetam or Oxiracetam + AlphaGPC as a choline donor. (many people have told me that they prefer the effects of Oxiracetam over the other two and as soon as I run out I'm switching over to Oxiracatam + Alpha GPC choline.
Okay, so after I got the omega-3, vitamins, piracetam + aniracetam + alphaGPC going I started looking into something called
"Acetyl-l-carnitine arginate is a patented form of carnitine that stimulates the growth of neurites in the brain. Studies show that acetyl-l-carnitine arginate stimulates the growth of new neurites by an astounding 19.5%, which is almost four times better than acetyl-l-carnitine.
The acetylated form of L-carnitine (acetyl-l-carnitine) facilitates the release and synthesis of acetylcholine by donating its acetyl group to the production of acetylcholine, an important neurotransmitter.14 Acetyl-lcarnitine also enhances the release of dopamine from neurons and helps it bind to dopamine receptors.15,16 Numerous human and animal studies validate the multiple beneficial mechanisms that acetyl-l-carnitine exerts in the brain.
Acetyl-l-carnitine is more effective than L-carnitine in carrying fatty acids across the membrane into the cell where they are burned as energy.17-20 Since 1995, Life Extension members have been supplementing with acetyl-l-carnitine and deriving the many benefits this form of carnitine has shown in published scientific studies. With the discovery of acetyl-l-carnitine arginate, the benefits of acetyl-l-carnitine can now be greatly augmented."
I enjoyed the effects but I found out that ALCAR (Acetyl-l-carnitine arginate for short) causes excess mitochondria free radical generation, and to combat this one should look into a mitochondrial anti-oxidant such as K R-Alpha lipoic Acid.
The R isomer of alpha lipoic acid has many benefits, not just anti-oxidant properties.
The benefits from this are subtle to me, but I feel like I have increased energy and motivation.
These things have mounting effects, I feel that I'm entering a state of vibrant "Megahealth" where I am nearly manic with happiness and joy of being alive and even if I were to quit all these supplements I feel that I would have lasting cognitive benefits.
"Sulbutiamine has been used to treat asthenia, a condition of low energy and lethargy usually reported by convelescing patients. There is some evidence that it does work and numerous patents regarding this material.
Sulbutiamine is described as a centrally acting cholinergic agent like donepezil which is used for Parkinson's and Alzheimer symptoms. These drugs inhibit the destruction of acetylcholine (a stimulating neurotransmittor) in the brain. Increased concentrations of acetylcholine are believed to be responsible for greater alertness, memory and acuity.
Sulbutiamine is an ACE inhibitor, which results in greater brain acetylcholine concentrations which would increase concentration, memory, alertness, etc.
"Sulbutiamine, a highly lipophilic thiamine derivative, is the only antiasthenic compound known to cross the blood-brain barrier and to be selectively active on specific brain structures directly involved in asthenia."
Wow! Sulbutiamine gets rid of my brain fog and fatigue, I actually want to go do stuff and get things done. This makes me manic in combinations with the aniracetam and choline!!
I drink alot of green tea for its antioxidant benefits, and mild stimulation from caffeine and theanine... I recently added theanine to my stack and it's awesome!
is a powerful GABA producing amino acid.
GABA (or gamma-aminobutyric acid)
is the primary inhibitive neurotransmitter in the brain. Everything from Alcohol and Benzodiazepenes (like xanax and valium) and even Opiates like Heroin increases GABA.
Daily I take around:
Sulbutiamine 400mg (I skip every 4th day)
8 to 10 grams of vitamin C
1000 I.U vitamin D
300mg Alpha GPC
2400mg fish-oil 75%epa (omega-3)
4 caps of ortho-core mutivitamin
500mg L-Tyrosine (cycled)
120mg ginkgo biloba
200mg R-Apha Lipoic Acid
3mg Melatonin, blueberry extract & resveratrol for their anti-oxidant benefits.
I may edit this post as I change my stack. I plan to add picamillon, L-carnosine and I want to test the other analogues of B vitamins, there are so many more nootropics out there that I'm going to try, you can see my random saved nootropic information links on del.icio.us here
I've read about the cognitive enhancement benefits of creatine, and I just added that to my stack... I'm going to be experimenting with it for a while and I'll let you know how it goes.
I drink from 5-10 cups of green tea daily!
I haven't had a drink of alcohol for over 5 months and I don't feel the need to, I don't plan on doing hard drugs again besides the ocassional trip, I get the choline benefits from sulbutiamine, with the gaba benefits and relaxation from theanine. I don't get a hangover or a come down... I'm motivated and happy!
You can check out my newfounded nootropics community here
I am by no means an expert on nootropics but I will gladly answer any of your questions!